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For constipation, the most common long-term GI side effect, a fiber supplement combined with increased water intake is the most effective approach

PMID: 20225319

"Unfortunately, many of these products have not been thoroughly tested or reviewed by the Food and Drug Administration, so we don't have data from trials

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Medicare Advantage beneficiaries had a higher likelihood of receiving angiotensin-converting enzyme inhibitors/angiotensin receptor blockers for coronary artery disease, tobacco cessation counseling, and screening for retinopathy, foot care and kidney disease (adjusted P .001 for all)