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Description

Most reported side effects of these peptides in studied doses are mild (injection-site irritation, transient sleep or vivid dreams, headaches), but longterm, largescale human safety dataespecially for longevity useremain limited

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TenhunenABvan der HeijdenJSkorupPMaccaranaMLarssonALarssonAet al

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21 , 30 , 31 The trigeminal nerve pathway allows nose-to-brain delivery through intracellular axonal transport and extracellular mechanisms, similar to those of the olfactory nerve pathway

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Strong biological rationale, but no RCT with cancer endpoints

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Centers for Disease Control and Prevention, 2024)

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However, drugs that block other receptors, such as alpha-2 adrenoceptors, dopamine D2 and D3 receptors, and serotonin 5-HT2A/C receptors, had no significant effect on tesofensines appetite-suppressing action

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