Most reported side effects of these peptides in studied doses are mild (injection-site irritation, transient sleep or vivid dreams, headaches), but longterm, largescale human safety dataespecially for longevity useremain limited
TenhunenABvan der HeijdenJSkorupPMaccaranaMLarssonALarssonAet al
21 , 30 , 31 The trigeminal nerve pathway allows nose-to-brain delivery through intracellular axonal transport and extracellular mechanisms, similar to those of the olfactory nerve pathway
Strong biological rationale, but no RCT with cancer endpoints
Centers for Disease Control and Prevention, 2024)
However, drugs that block other receptors, such as alpha-2 adrenoceptors, dopamine D2 and D3 receptors, and serotonin 5-HT2A/C receptors, had no significant effect on tesofensines appetite-suppressing action