G., Granzow, H
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It plays a role in conditions like PCOS and endometriosis, and tends to increase naturally with age
The gut-joint axis: microbial dysbiosis and OA Emerging evidence firmly establishes a link between gut microbiota dysbiosis and OA progression, primarily mediated by microbial metabolites via the gut-joint axis. The core protective mechanism involves short-chain fatty acids (SCFAs) like butyrate and propionate, produced from dietary fiber fermentation by commensals such as Bacteroides and Faecalibacterium prausnitzii
It is argued that NOX2, the primary isoform in microglia, is thought to be the major contributor of SE-induced ROS production in acquired epilepsies, which has also been linked to glucose hypometabolism in epileptogenesis (Zilberter et al., 2022)
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