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44,45 In response to overnutrition, obesity and insulin resistance, beta-cells adapt by increasing their mass and/or number, both of which result in increased capacity of insulin secretion

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ORCID: Affiliation: 6 Instituto de Farmacologia e Neurocincias, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal 7 Centro Cardiovascular da Universidade de Lisboa, CCUL (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal These authors contributed equally to this work