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Additionally, the clinical presentation of G6PD-deficient patients may vary, so a well-designed large-scale clinical study or an animal model scalable to the human immune system would be required in order to provide sufficient evidence of this point

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While betaine supports methylation and osmoregulation, excess levels can drive the production of TMAO via gut microbiota, an established contributor to atherosclerosis and cardiac dysfunction (106, 107)

When the body metabolises fat stores quickly, the liver secretes extra cholesterol into bile, which can crystallise and form stones

[DOI] [PubMed] [Google Scholar] 95.Ames B.N., Shigenaga M.K., Hagen T.M

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