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10.1089/ten.TEB.2019.0351 56 InoueT.MikiY.AbeK.HatoriM.HosakaM.KariyaY.et al (2011)

By blocking IL-23 and reducing levels of Th17 effector molecules like IL-17, IL-22, chemokines, and -defensin, Etanercept and other TNF- inhibitors accomplish their immunological purpose

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Yet, a large number of clinical trials have failed to show beneficial effects of antioxidants for these pathologies, and a handful of trials have suggested that antioxidants increase mortality