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Under normal cellular conditions, Keap1 tethers Nrf2 in the cytoplasm (the region of the cell outside the nucleus), where it can be tagged and delivered for degradation

Randomization and blinding Participants entering Phase II were randomized to one of two intervention sequences (pomegranate followed by placebo, or placebo followed by pomegranate) in a single block of 20

Appropriate use increased from 62% in phase 1 to 72% in phase 2 of the audit

The analysis focused on three classes of antidiabetic medications: GLP-1RAs, DPP-4is, and SGLT-2is

Almost immediately, a large portion is converted to norcyclobenzaprine in the liver