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L-Carnitine inhibits protein glycation in vitro and in vivo : evidence for a role in diabetic management

doi: 10.1016/j.tox.2017.08.002 77 WallaceDC

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However, while these experiments did not distinguish which KCC may be involved in the stimulatory effects of high doses of the diuretic, inhibition of -cell KCC2 with highly selective drugs (Kursan et al., 2017) or its transient siRNA-mediated downregulation in islets (Pae and Harper, 2021) resulted in increased insulin secretion in response to glucose