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Bruno et al., 2006), especially in cases of oxidative stress or other antioxidant deficiencies (Traber and Atkinson, 2007)

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In preclinical treatment models, the HDACi have exhibited neuroprotective effects and stimulation of neurogenesis in traumatic brain injury and ischemia (Kim et al., 2009), restoration of memory and learning in traumatic brain injury in neurodegenerative mice (Vecsey et al., 2007) and exerted antidepressant-like effects (Schroeder et al., 2007)