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Strikingly, sporadic mutation of equivalent arginine residues in the HRD motifs of unrelated protein kinases are similarly catastrophic and cause rare, monogenic forms of various human diseases [145,146,147,148,149]

The Scandinavian PROLONG (PROtective genetic and non-genetic factors in diabetic complications and LONGevity) initiative in Sweden and Denmark was launched aiming to identify clinical, metabolic and genomic factors promoting protective mechanisms in individuals with long-term T1D who have escaped from the development of diabetic complications

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