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This simplicity reduces the likelihood of missed doses

Other activators of pancreatic beta cells Incretin hormone receptor agonists (discussed below) can reduce beta cell apoptosis in vitro and in animal models, probably via cAMP and protein kinase A (PKA) activation, and provide the best evidence-supported opportunity to preserve the beta cell population at this time

Similarly, Gallon et al

Potential concerns about lifelong use include pancreatitis history (a contraindication), thyroid changes that require monitoring, and dehydration risk if fluid intake isn't adequate

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It's not meant to be long-term, as it can limit fiber and beneficial prebiotics