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The NEJM trial, the PMC review by Katsi et al

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GLP1 analogues work on the gut-brain hormone axis, the powerful mechanism that controls our hunger and very importantly our satiety, sending messages to our brain that we are full, making us less hungry and thereby leading to less food being consumed

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Safety of GLP-1 RAs during pregnancy Animal studies consistently demonstrate teratogenic risks at supratherapeutic doses, including skeletal anomalies and fetal growth restriction [28]

Rapid weight loss can result in muscle loss alongside fat loss, which negatively impacts metabolic health long-term