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In a rat model of ischemic stroke, administration of the herbal compound Salvia miltiorrhiza extract modulated gut microbiota composition, reduced infarct size, and decreased markers of inflammation and oxidative stress, indicating a gut-mediated neuroprotective effect (Wu J

doi: 10.1038/cdd.2015.93 99 CaoJChenXJiangLLuBYuanMZhuDet al

Reduced Inflammation Studied for modulation of systemic inflammation in preclinical models