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doi:10.1016/S0015-6264(73)80326-8.[Crossref], [PubMed] , [Google Scholar]

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Practical management strategies: Eat smaller meals more frequently rather than large meals Avoid high-fat and greasy foods during dose escalation periods Stay well hydrated throughout the day Time your injection when minor nausea will be least disruptive Consider avoiding foods that commonly trigger nausea (spicy, acidic, very sweet) Decreased appetite versus loss of appetite There is an important distinction between healthy appetite suppression and appetite loss that crosses into problematic territory

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3.2 Opioids Although opioids such as morphine, remifentanil, heroin, and oxycodone largely share a common pharmacologic mechanism of action, namely, acting on opioid receptors, the ability of GLP-1R to regulate the behavioral responses to these opioids varies