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There are a few side effects that can happen with too big of a calorie deficit, as noted by Cleveland Clinic, such as: Fatigue Nausea Dehydration Constipation Heachaches Crabbiness Nutrition influences how the body responds to weight loss

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4.2 Brain Effects Neuroimaging studies have been employed in attempts to explore the central mechanisms of action of GLP-1 and its analogs

Weight loss continues at a steady pace, and appetite suppression becomes more consistent

This typically happens after a few weeks or when the dosage stabilises

Beyond lipid metabolism, GLP-1RAs exert profound effects on mitochondrial homeostasis in retinal neurons