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Most gastrointestinal side effects with both medications occur during dose escalation and reduce significantly over time

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The main difference is that semaglutide has a slightly longer half-life, which means even more timing flexibility, and a shorter minimum interval between doses (48 hours versus 72 hours)

If the TRIUMPH trials finish enrollment on schedule and read out in late 2025 or early 2026, Lilly could file an NDA in mid-to-late 2026

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