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The location of the PSPH gene on chromosome 7p11.2 is in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, WBS (also called Williams syndrome, WS)

Finally, vitamin B12 is crucial for the biochemistry of the nervous system, participating in DNA synthesis, methionine synthesis, methylation reactions, myelin synthesis, and neurotransmitter production (, , , , , , )

These changes were even more pronounced in individuals with HFrEF, 46 where increased cardiac expression of the fission regulatory protein, dynamin-related protein-1, and decreased mitochondrial complex IV activity were also observed