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Mohammadi, A., Gholamhoseyniannajar, A., Yaghoobi, M

Semaglutide helps approximately 6070% of users lose at least 5% of their body weight within six months, yet some people experience minimal results despite consistent use

SAM allosterically activates mammalian CBS 2.5-5 fold (Janosik et al., 12 deficiency, methionine block implies that SAM (driven by Met) is lowered as well and hence it is plausible CBS is less effective

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Option 1: FDA-approved injectable tirzepatide Brand names Mounjaro (for type 2 diabetes) and Zepbound (for weight management) remain the gold standard