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Although multiple pathways are involved in mediating tissue damage, including the polyol pathway, advanced glycation end product formation, protein kinase C activation, and the hexosamine pathway, a common feature is increased oxidative stress marked by elevated levels of reactive oxygen species (ROS) (1)

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doi:10.1016/j.mocell.2024.100113 Thompson EL, Pitcher LE, Niedernhofer LJ, Robbins PD

Indeed, several studies have reported mitochondrial elongation following exposure to compounds that either impair or enhance mitochondrial respiration, including Rot and NAM 11,68,74,75

In addition, glutathione protects cells from damage caused by oxidative stress, which can help slow down the aging process and prevent diseases linked to cell oxidation