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It does not mean unapproved drugs are unsafe

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In mice, for example, moderate hyperglycemia results in an increased rate of neuronal differentiation from RG and early cell cycle exit

Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)