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Phase 1 clinical trial using hyperglycemic clamp The study was in compliance with the CONSORT statement (Supplementary Information Note 1)

Genetic predisposition Unfortunately, there is little consensus among researchers on the genetic, cellular, and molecular influences that alter the risk of developing ME/CFS (61, 6568) as members of the same family have frequently been diagnosed with ME/CFS (65, 67, 68), though they will also tend to share similar lifestyles and cultures

6 Inhibiting the DPP-4 enzyme enhances the action of GLP-1 by prolonging the half-life and increasing circulating GLP-1