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Elafibranor and nitazoxanide synergize to reduce fibrosis in a NASH model

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The direct administration of microbiota-derived metabolites, such as short-chain fatty acids (SCFAs) and indole derivatives, has been shown in experimental models to improve insulin sensitivity, reduce inflammation, and promote gut hormone secretion, potentially bypassing the need for sustained microbial engraftment (112)

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For mitochondrial fraction analysis, mitochondria were isolated using a differential centrifugation procedure as described by Fernndez-Vizarra et al