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Subsequent in vivo work in transected tendon and ligament models has reproduced these findings and added documentation of accelerated collagen deposition, growth-hormone receptor upregulation, and improved biomechanical recovery markers
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The intrinsic factor-mediated pathway operates regardless of food presence, and the passive diffusion mechanism (responsible for absorbing about 1% of high doses) similarly functions independently of meals
This notion is also supported by the observation that ACE inhibitors enhance cognitive processing in both humans (65, 66) and animal models (67)
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