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A gut bacterial amyloid promotes alpha-synuclein aggregation and motor impairment in mice

When a drug binds extensively to components outside the plasma, such as proteins in muscle or lipids in adipose tissue, only a small fraction of the total drug in the body remains in the plasma to be measured

They work through fundamentally different mechanisms

Both contribute to the normal protection of cells from oxidative stress and the normal function of the immune system

The controlled human evidence is weaker than often claimed

While semaglutide alone has been revolutionary, adding cagrilintide pushes weight loss results into territory before achievable only through bariatric surgery