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Moreover, several PD-associated genes, such as PINK1, Parkin, DJ-1/PARK7, the Leucine-rich repeat kinase2 ( LRRK2 ), the Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 ( CHCHD2 ), VPS35 and the tumor necrosis factor receptor associated protein 1 ( TRAP1 ), have been shown to be involved in OXPHOS regulation [88] (Table 2)

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Visschers et al., 2012

Treatment may include dietary changes, supplements or vitamin B12 injections, depending on the cause and severity of the deficiency