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Stacked graphs refer to different phase of cell cycle: S phase, Apoptosis, G2/M, G0/G1

ACC/AHA In 2019, the ACC and AHA published Guidelines on Primary Prevention of Cardiovascular Disease, suggesting that GLP-1 RA may help reduce CVD risk in patients with T2DM who require glucose-lowering medications despite lifestyle changes and use of metformin (Class 2a, Level of Evidence (LoE) B-R) [42]

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however, additional studies are needed to elucidate the extent of achievable improvements, generalizability to other obesity management medications, and risks of weight regain during longterm treatment