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The primary cardiovascular end-point event occurred in 569 of the 8803 patients (6.5%) in the semaglutide group and 701 of the 8801 patients (8.0%) in the placebo group (Lincoff et al

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Semaglutide binds to GLP-1 receptors in the brain, particularly in the hypothalamus, reducing hunger signals and increasing satiety

Bioavailability determines what percentage of the injected dose actually reaches systemic circulation

Given the known role of Y1-R in GLP-1R-mediated regulation of insulin secretion, we were surprised to find that Y1-R also stimulated glucose uptake in muscle via a mechanism that was fully independent of insulin stimulation

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