Nicotinamide and EGCG reduce A accumulation and protein oxidation in aged 3xTg-AD hippocampal neurons Since intracellular A aggregates increase across the lifespan of the 3xTg-AD model in vivo [38], and in vitro [1] and a hallmark for brain aging and the progression of AD is protein oxidation, including tyrosine nitration [1, 39], we immunostained neurons for A accumulation and protein nitration and evaluated the effects of treatment with nicotinamide and EGCG
doi:10.1177/15648265080292S129
There have been some fears that the "research only" loophole would be cracked down on as well, and some are stockpiling Semaglutide, Tirzepatide, and Retatrutide, which can be safely stored for up to 2 years
Thomas-OdenthalFRingwaldKTeutenbergLSteinFAlexanderNBonnekohLMet al
More concerning are cognitive side effects, sometimes nicknamed dope-a-max by patients because the drug can cause word-finding difficulties, slowed thinking, and memory issues
Transfusion , 56 11, 2824-2832 Hegde, Shailaja