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2019, 7, 12951301 Harada, E., Morizono, T., Kanno, T., Saito, M., & Kawagishi, H

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Although our study found that IL-16 lost its anti-tumor function after the depletion of CD4 + cells, this finding does not rule out the possibility that IL-16 acts on a non-CD4 receptor, which is primarily expressed on CD4 + cells

As a result, investigators are interested in arginine deprivation as a strategy for shrinking tumors because it decreases inflammatory NO, insulin-like growth factor 1 (IGF-1) and mTOR

I remember trying to justify the value of statins to payers in late 90s when they were costing one dollar and change a day to insurers