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doi: 10.1161/CIRCULATIONAHA.109.924977

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H-D-Phe-Arg(HCl)-Trp-Lys( Boc)-NH 2 ( 8 ) Protected tetrapeptide 7 (239 g, 263.9 mmol) was dissolved in methanol (1.4 L), and Pd(OH) 2 (6.6 g) was added

The peptide appears to act as a broad neuromodulator rather than through a discrete pharmacological target

Additionally, the LEADER study reported a post-hoc analysis in patients with polyvascular disease (defined as atherosclerosis in two or more of the following vasculature territories: ocular, coronary arteries, cerebral arteries or arteries peripheral), in which they did not observe significant differences in the risk of non-fatal stroke in the liraglutide group versus placebo [63]