However, not enough is known about this theoretical issue to elucidate a risk-benefit tradeoff and how timing of treatment works into such a tradeoff

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How often IV B12 is given can vary from weekly to monthly, depending on how the patient responds and the reason for the deficiency
& Saharan, S
Perhaps have a read of this: pernicious-anaemia-society
Comparison: MOTS-c + 5-Amino-1MQ Synergy vs Monotherapy Key Takeaways MOTS-c activates AMPK to increase mitochondrial function and fat oxidation, while 5-Amino-1MQ inhibits NNMT to preserve NAD+ poolstargeting complementary metabolic pathways