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Multiple factors can lead to mitochondrial dysfunction in PD, ultimately affecting ATP synthesis

Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, et al

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When macrophages and other immune cells engulf pathogens or damaged tissue debris, they generate large amounts of ROS, such as superoxide anions, hydrogen peroxide, via respiratory burst (148)

Ca serum level is not typically reduced, which can be explained by the fact that Ca plays many critical physiological roles (e.g., nerve communication, blood coagulation, hormonal regulation), so the body keeps the blood levels by reducing bone mineralization