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Glycaemic efficacy GLP-1RAs are one of the most potent antihyperglycaemic classes, with subcutaneous semaglutide exerting the greatest effects on glycated haemoglobin (HbA 1c ), with a difference compared with placebo of 1.33 percentage points (95% confidence interval [CI] 1.50 to 1.16 percentage points), followed by dulaglutide and exenatide in a descending order of potency

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