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Because many GLP-1 therapies are prescribed to individuals with obesity or metabolic syndrome, separating medication effects from underlying risk factors can be difficult

These effects often diminish over time

Makes it relatively painless

For example, senolyticscompounds that selectively clear senescent cells that accumulate with age (Riessland and Orr, 2023)may reduce inflammation associated with the senescence-associated secretory phenotype (see Chapter 3)

Case reports in the Supplementary Material exemplify the possibility of more flexible approaches in the timing of administration

By delaying gastric emptying, semaglutide may alter the rate and extent of absorption of orally administered medications, particularly those requiring rapid absorption for optimal effect or those with a narrow therapeutic window