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They work through different mechanisms: phentermine is a sympathomimetic that suppresses appetite via norepinephrine release
Acknowledgements We acknowledge the EMBION Cryo-EM Facility at Aarhus University (application #0137)
Theres no requirement or strong rationale to try Saxenda first
Adjusted eGFR decline = 14.48 eGFR at baseline 0.087 + 1.504 (if female) 0.069 Age + 0.052 BW - 0.097 BMI - 0.018 SBP - 0.032 DBP - 0.048 HbA1c (mol/l) + Treatment periods(months) 0.022
This combinatorial approach may ultimately prove more flexible than the all-in-one triple-agonist strategy, because it allows each component to be dosed independently and titrated to individual response
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