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Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are effective in improving liver inflammation in patients with MASLD

The figure below summarizes that, to date, the structures of eight different small molecule agonists have been resolved, all of which are located near the extracellular ligand-binding pocket compared to the GLP-1 peptide

Recent studies have shown that GLP-1R agonists can significantly improve hepatic fat content and liver function indexes in patients with MASLD, thereby reducing the risk of progression to Chronic Liver Disease in patients with MASLD (Singh et al., 2024

For each patient, the risk-benefit tradeoff critically depends on a patients clinical characteristics and their preferences and clinicians recommendations, senior study author Rong Xu, PhD, professor and director of the Center for AI in Drug Discovery at Case Western Reserve University, told Healthline

The findings revealed a crucial insight, for some GLP-1 s like Saxenda and Wegovy, the high cost of ongoing use surpasses the cost of RYGB in less than a year and sleeve gastrectomy within nine months

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