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Samocha-Bonet, D., Wong, O., Synnott, E.-L., Piyaratna, N., Douglas, A., Gribble, F

Metformin does not directly stimulate insulin release and has been a first-line diabetes treatment for over 50 years

It's important to note that hair loss (alopecia) is listed as an adverse reaction in the Summary of Product Characteristics (SmPC) for semaglutide 2.4 mg (Wegovy), though it is not listed as a common side effect for other GLP-1 medications such as Ozempic, Saxenda, or Trulicity

Robert Gabbay MD, PhD, the reassurance here is important

Some probiotic products require refrigeration, but Pendulum formulations use delayed-release capsules and specific manufacturing processes designed to maintain stability at room temperature

Tirzepatide (when added to metformin) can reduce A1c by up to 2.3%