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The more lipidated the apoA-1 becomes, the discoidal HDL particles transition into a spherical structure and lose their ability to interact with ABCA1 and stimulate cholesterol efflux through ABCA1

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In February 2025, MHRA figures revealed 82 deaths linked to GLP-1s up to January 2025, 22 of which were related to their use for weight-loss purposes 14

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Throughout the manuscript, we critically evaluate the hierarchy and reliability of the evidence by specifically emphasizing methodological limitations, study design flaws, the presence or absence of placebo controls, and baseline population equality