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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162

Our data demonstrated that C10:2 promoted the expression of PCNA, cyclinA and CDK2, indicating enhanced the combination of cyclinA and CDK2 to form the S-phase landmark complex cyclinA-CDK2 to control cell cycle and stimulate DNA synthesis in PASMCs [31, 32]

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Vitamin C: Known for its antioxidant properties, vitamin C can help reduce oxidative stress and contribute to skin brightening

Two-side p-values are reported