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The neuroprotective effects are linked to the activation of the cAMP/PKA/pCREB pathway [45]

For protein precipitation and metabolite extraction, 25 l of plasma and diluted urine were added to 1.5 ml Eppendorf tubes, along with 225 l of methanol and 10 l of internal standard (IS) of both substances

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Used in research planning when more precise dose control is wanted

21 CruccuG.Di StefanoG.FattappostaF.JannS.PaduaL.SchenoneA.et al (2017)