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Youll find no shortage of online stories about dramatic weight loss with berberine, seemingly highlighting its efficiency, but what does the science say

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Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)

semaglutide 2 mg, N = 480)

Meyhfer, Jens Aberle: The authors have received honoraria for speaking at symposia, financial support for attending symposia, financial support for educational programs, and consultation from Novo Nordisk

These changes arent cosmetic