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Retatrutide activates three hormone receptorsGLP-1, GIP, and glucagoncompared to semaglutides single pathway

Adipose tissue retains an epigenetic memory of obesity after weight loss

Semaglutide functions by mimicking a hormone that regulates appetite

GLP-1 receptor activation also influences fluid and electrolyte secretion in the intestinal mucosa, which may contribute to changes in stool consistency

232 Several studies have demonstrated that loss of function of UBE3A leads to increased ARC expression and subsequently decreases the number of AMPARs, ultimately impairing synaptic plasticity at excitatory synapses