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In conclusion, GLPs maintain the homeostasis of the renal microenvironment and alleviate renal fibrosis through multiple targets, such as anti-oxidation, anti-inflammation, anti-apoptosis, regulation of lipid metabolism, and blocking relevant pathways, formulating a theoretical framework to support the research and creation of novel pharmacological treatments for nephropathy

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Knocking down ACTL6A had no impact on NRF2 expression (Supplementary Fig 6h)