Furthermore, measurements have shown that human breast tumors display plastic deformation (i.e., permanent deformation when subjected to external forces) [144], likely due to the increased collagen concentration and crosslinking observed in the breast tumor microenvironment which can enhance plasticity [145]
Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M
Clemmensen C, Finan B, Mller TD, DiMarchi RD, Tschp MH, Hofmann SM (2019) Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
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Moreover, more importantly, the mitotic count was up to 2 /10HPFs, which may have been a factor attributing to the lung metastasis
Its naturally high presence in human milk, particularly in colostrum , highlights its essential role in early infancy