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Our findings suggest that metformin has a greater predicted neuroprotective impact compared to 38 other DM2 DMTs, including semaglutide, that target the DM2-AD comorbidity network, primarily by engaging key metabolic and neuroinflammatory pathways and by indirectly modulating viral-associated mechanisms relevant to AD pathology

doi: 10.1111/dom.14580 23 LiYGlotfeltyEJKarlssonTFortunoLVHarveyBKGreigNH