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Symptoms may include: Fatigue Joint or muscle pain Digestive issues Rashes or skin problems While GLP1 medications arent proven to cause autoimmunity, they appear to modulate immune activity sometimes dampening inflammation, other times triggering unwanted immune responses
GLP-1R activity also promotes the transactivation of epidermal growth factor receptor (EGFR), which then signals through phosphoinositide 3-kinase (PI3K) and insulin receptor substrate-2 (IRS-2), and subsequently activates extracellular-signal-regulated kinase 1 and 2 (ERK1/2) and nuclear translocation of PKC to mediate -cell proliferation and differentiation (110, 114)
Its discovery is related to the development of a new hypothesis regarding the regulation of growth hormone secretion
PINK1 KO in human and mouse DA neurons causes decreases in membrane potential and increases in ROS generation (Wood-Kaczmar et al., 2008)
Skin and subcutaneous tissue disorders Less frequent: Cases of acne or eczema have been reported after high doses of Vitamin B12
