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In HD, there can also be disturbances in transcription and synaptic dysfunction [168], as well as deletions in mtDNA (mtDNA4977), particularly in mitochondria from the frontal and temporal lobes

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This may make it a more sensitive indicator of GFR, and thus of kidney disease (Newman 1995

In order to provide more clinically relevant information to clinicians (i.e., the potential dose-dependent risk of hearing loss), we conducted a subgroup analysis by grouping RCTs by various dosages of individual medication, which procedures had been widely accepted in various fields of research [22,23,24]

Some of my current work involves understanding that better. Some fiber-rich foods like leafy greens are inherently light and easy to digest, but others can be tougher, especially for GLP-1 diners