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Thoughtful consideration of selection of initial therapy, management of drug dosing, and use of adjunctive therapies throughout the course of PD is necessary to optimize long-term therapeutic outcomes and minimize adverse effects
Additionally, the GH stimulatory effect on the liver to increase IGF-I secretion is accentuated by the direct GH effects in antagonizing insulin action and suppressing the anti-lipolytic actions of insulin (68)
GH secretagogues to preserve muscle mass during caloric deficit
Nitric oxide mediates noradrenaline-induced hypothermic responses and opposes prostaglandin E2-induced fever in the rostromedial preoptic area