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As already highlighted, these glands have high GLP-1R expression in both rodents and humans, and liraglutide has been shown to upregulate genes encoding mucins in the Brunner's glands of mice (73, 87, 249), which may reduce intestinal permeability and improve systemic inflammation (250)

The New England Journal of Medicine, 391 (2), 109121

However, GLP-1RA exenatide has been shown to enhance functional connections in the hypothalamus, nucleus tractus solitarius, and thalamus