However, the body's natural GLP-1 system sometimes works against us, especially in individuals with obesity, who may not experience as much GLP-1 release
doi: 10.3389/fendo.2022.1062790 28 HornsteinMD
Attractive targets include members of the LOX family, namely LOX and LOX-like 2 (LOXL2), which mediate collagen and/or elastin crosslinking [97, 98], thereby contributing to ECM remodeling in the tumor microenvironment
This is because you have more of the drug to clear from your system (but your side effects should still start decreasing after about one week)
Its therapeutic activity may not involve an AT mechanism
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